Codeine has actually been reported to point out no evidence of carcinogenicity or mutagenicity in a variety of take a look at systems, including the micronucleus and sperm abnormality assays as well as the Salmonella assay. Promethazine was nonmutagenic in the Salmonella take a look at system of Ames.benzhydrocodone/acetaminophen and promethazine t